Numerical modeling of interstitial fluid pressure in solid tumors : the importance of the lymphatic system

Theoretical and experimental research showed that the interstitial fluid pressure (IFP) is elevated in solid tumors compared to normal tissue, resulting in a poor prognosis and treatment resistance. Although the lymphatic vessels are known to be partially impaired in solid tumors, the impact of the lymphatic system on IFP profiles in tumors is currently not fully understood. Here, we present a 3D computational fluid dynamics (CFD) approach to study the link between the lymphatic system and the IFP in solid tumors